The PPARGC1B Polyclonal Antibody (CAB17258) is a valuable tool for researchers studying PPARGC1B, a transcriptional coactivator involved in the regulation of cellular energy metabolism. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By targeting the PPARGC1B protein, this antibody enables the detection and analysis of PPARGC1B expression in various cell types, making it a valuable asset for studies in metabolism, diabetes, and mitochondrial function.PPARGC1B, also known as PGC-1β, plays a pivotal role in the regulation of mitochondrial biogenesis and oxidative metabolism, making it a key player in energy homeostasis and metabolic health.
Dysregulation of PPARGC1B has been implicated in metabolic disorders such as diabetes, as well as neurodegenerative diseases and cardiovascular conditions. By understanding the function and regulation of PPARGC1B, researchers can gain insights into the pathophysiology of these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
PGC1 beta Rabbit Polyclonal Antibody
SKU:
CAB17258
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human PGC1 beta (NP_001166170.1).
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
133522
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using PGC1 beta Rabbit pAb (CAB17258) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5min.
