The PPARGC1B Polyclonal Antibody (CAB17257) is a valuable tool for research involving PPARGC1B, a transcriptional coactivator involved in the regulation of energy metabolism and mitochondrial biogenesis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.PPARGC1B, also known as PGC-1beta, plays a crucial role in the regulation of cellular energy metabolism by promoting the expression of genes involved in oxidative metabolism and mitochondrial function. Dysregulation of PPARGC1B has been implicated in various metabolic disorders, such as obesity, diabetes, and cardiovascular diseases.
By studying the expression and function of PPARGC1B, researchers can gain insights into the molecular mechanisms underlying these conditions and identify potential therapeutic targets.With its high reactivity and specificity, the PPARGC1B Polyclonal Antibody is an indispensable tool for investigating the role of PPARGC1B in health and disease. Whether studying metabolic pathways, mitochondrial function, or the development of metabolic diseases, this antibody enables accurate detection and analysis of PPARGC1B in various experimental settings.
Product Name:
PGC1 beta Rabbit Polyclonal Antibody
SKU:
CAB17257
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human PGC1 beta (NP_001166170.1).
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
133522
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PGC1 beta Rabbit pAb (CAB17257) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
