The PPARGC1A Polyclonal Antibody (CAB11971) is a powerful tool for researchers studying PPARGC1A, a transcriptional coactivator involved in regulating cellular energy metabolism and mitochondrial biogenesis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.PPARGC1A, also known as PGC-1 alpha, plays a crucial role in regulating genes involved in mitochondrial function and biogenesis, making it a key player in cellular metabolism and energy production. Dysregulation of PPARGC1A has been implicated in various metabolic disorders, neurodegenerative diseases, and even cancer.
By using the PPARGC1A Polyclonal Antibody, researchers can effectively detect and analyze PPARGC1A protein expression in a variety of cell types, providing valuable insights into its function and potential therapeutic implications. This antibody is an essential tool for studies exploring the role of PPARGC1A in metabolic disorders, neurodegenerative diseases, and cancer, ultimately leading to a better understanding of cellular energy regulation and potential treatment strategies.
Product Name:
PGC1α Rabbit Polyclonal Antibody
SKU:
CAB11971
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 610-710 of human PGC1α (NP_037393.1).
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Purification Method:
Affinity purification
Gene ID:
10891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using PGC1α Rabbit pAb (CAB11971) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
