The PPARG Polyclonal Antibody (CAB0270) is specifically designed for research involving PPARG, a nuclear receptor protein known for its role in regulating genes involved in adipocyte differentiation, lipid metabolism, and insulin sensitivity. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications.PPARG, also known as peroxisome proliferator-activated receptor gamma, is a key regulator of glucose and lipid metabolism, making it a crucial target for research in obesity, diabetes, and metabolic disorders. By targeting PPARG with this polyclonal antibody, researchers can detect and analyze the protein in various cell types, providing valuable insights into its function and potential as a therapeutic target.
Understanding the role of PPARG in metabolic regulation is essential for developing novel treatments for metabolic diseases and improving overall human health. This antibody serves as a valuable tool for studying PPARG function in both normal physiological conditions and disease states, offering researchers the opportunity to advance our understanding of metabolic pathways and potential therapeutic interventions.
Product Name:
PPARγ Rabbit Polyclonal Antibody
SKU:
CAB0270
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PPARγ (NP_056953.2).
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
5468
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded mouse heart using PPARγ Rabbit pAb (CAB0270) at dilution of 1:200 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
