The PPARδ Polyclonal Antibody (CAB5656) is designed for research involving PPARδ, a nuclear receptor known for its role in regulating metabolism and inflammation. The antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications. It binds specifically to the PPARδ protein, allowing for the detection and analysis of its expression in a variety of cell types.PPARδ, also known as PPAR-beta, plays a crucial role in lipid metabolism, energy homeostasis, and the regulation of inflammatory responses. Its involvement in these key physiological processes makes it a significant target for research in the fields of metabolic disorders, cardiovascular disease, and inflammation.
Investigating the function of PPARδ is essential for understanding its potential as a therapeutic target in these disease contexts.Overall, the PPARδ Polyclonal Antibody (CAB5656) is a valuable tool for researchers studying the biological functions of PPARδ and its implications in various disease pathologies. Its high specificity and reliability make it an ideal choice for immunology and metabolic research endeavors.
Product Name:
PPARD Rabbit Polyclonal Antibody
SKU:
CAB5656
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 102-361 of human PPARD (NP_803184.1).
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
Purification Method:
Affinity purification
Gene ID:
5467
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PPARD Rabbit pAb (CAB5656) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
