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OCT4 Rabbit Polyclonal Antibody (CAB7920)

SKU:
CAB7920
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-OCT4 Antibody CAB7920
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-OCT4 Antibody CAB7920
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:OCT4 Rabbit Polyclonal Antibody
SKU:CAB7920
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 210-310 of human 4-oct (NP_002692.2).
Sequence:EADN NENL QEIC KAET LVQA RKRK RTSI ENRV RGNL ENLF LQCP KPTL QQIS HIAQ QLGL EKDV VRVW FCNR RQKG KRSS SDYA QRED FEAA GSPF SGGP V
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; Oct3/4
Positive Sample:Mouse embryo
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:39kDa
Observed MW:45kDa

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Purification Method:Affinity purification
Gene ID:5460
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse embryo, using OCT4 Rabbit pAb (CAB7920) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.

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