The POU2F1/POU2F2 Polyclonal Antibody (PACO01196) is a vital tool for researchers studying the POU2F1 and POU2F2 transcription factors. These transcription factors are known to play critical roles in gene regulation, cell differentiation, and development processes. The antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.POU2F1 and POU2F2 are essential for the proper functioning of various cell types and tissues, and dysregulation of these factors has been linked to several diseases, including cancer and developmental disorders.
By using the POU2F1/POU2F2 Polyclonal Antibody, researchers can investigate the expression levels and activity of these transcription factors in different cell types, providing valuable insights into their roles in normal physiology and disease pathways.Overall, the POU2F1/POU2F2 Polyclonal Antibody is a reliable tool for studying the functions of POU2F1 and POU2F2 in various biological processes, offering researchers the opportunity to advance our understanding of gene regulation and cell biology.
Antibody Name:
POU2F1/POU2F2 Antibody
Antibody SKU:
PACO01196
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from human 41183 around the non-phosphorylation site of S385.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
POU2F1; OCT1; OTF1; POU domain; class 2, transcription factor 1; NF-A1; Octamer-binding protein 1; Oct-1; Octamer-binding transcription factor 1; OTF-1; POU2F2; OCT2; OTF2; POU domain, class 2, transcription factor 2; Lymphoid-restricted im
UniProt Protein Function:
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
NCBI Summary:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
