The POU2F1 Monoclonal Antibody (MACO0063) is a valuable tool for researchers studying the POU2F1 protein, also known as Oct-1, which is a transcription factor involved in regulating gene expression. This antibody, produced in mice, specifically targets POU2F1 and is highly reactive with human samples.Validated for use in techniques such as Western blot and immunohistochemistry, the POU2F1 Monoclonal Antibody allows for precise detection and analysis of POU2F1 expression in various cell types and tissues. This makes it an ideal choice for research in the fields of molecular biology, genetics, and cancer research.
POU2F1 plays a crucial role in controlling the activity of genes involved in cell growth, differentiation, and development. By studying POU2F1 expression and function, researchers can gain valuable insights into the molecular mechanisms underlying various physiological processes and diseases. The POU2F1 Monoclonal Antibody provides a reliable tool for investigating the role of POU2F1 in gene regulation and cellular processes, making it indispensable for advancing scientific knowledge in this field.
Product Name:
Anti-POU2F1 Antibody
Product Sku:
MACO0063
Size:
50ug
Host Species:
Mouse
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:5000
Species Reactivity:
Human
Immunogen:
Synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clonality:
Monoclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Background:
Synonyms:
POU domain class 2 transcription factor
Western blot analysis of 1) Hela, 2) Jurkat, 3) HepG2, diluted at 1:2000
UniProt Protein Function:
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
NCBI Summary:
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
