The POT1 Polyclonal Antibody (CAB1491) is a valuable tool for researchers studying the POT1 protein, a crucial component of telomere maintenance and genome stability. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the POT1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for investigations in the fields of genetics and cancer research.POT1, also known as protection of telomeres 1, plays a vital role in protecting chromosome ends and regulating telomere length, which is essential for maintaining genomic integrity and preventing cellular aging.
Mutations in POT1 have been associated with various diseases, including cancer and dyskeratosis congenita. By understanding the function of POT1, researchers can gain insights into how telomere maintenance impacts disease development and potentially identify new therapeutic targets for treating genetic disorders and cancers.Overall, the POT1 Polyclonal Antibody (CAB1491) offers researchers a reliable tool for studying the role of POT1 in telomere biology and genomic stability, with implications for understanding disease mechanisms and developing targeted therapies.
Product Name:
POT1 Rabbit Polyclonal Antibody
SKU:
CAB1491
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 497-634 of human POT1 (NP_056265.2).
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
25913
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using POT1 antibody (CAB1491) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
