The CYPOR Polyclonal Antibody (CAB5032) is a key tool for researchers studying cytochrome P450 oxidoreductase (CYPOR), an essential enzyme involved in drug metabolism and steroid biosynthesis. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the CYPOR protein, this antibody enables accurate detection and analysis in a variety of cell types, making it invaluable for investigations in pharmacology and toxicology.CYPOR plays a crucial role in the activation of various drugs and xenobiotics by facilitating their metabolism in the liver.
Disruption of CYPOR function has been implicated in drug toxicity and drug-drug interactions, highlighting the importance of studying this enzyme in drug development and personalized medicine. The CYPOR Polyclonal Antibody offers researchers a reliable tool for exploring the function and regulation of CYPOR in health and disease, paving the way for novel therapeutic interventions targeting drug metabolism pathways.
Product Name:
CYPOR Rabbit Monoclonal Antibody
SKU:
CAB5032
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human CYPOR (P16435).
This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase.
Purification Method:
Affinity purification
Gene ID:
5447
Clone Number:
ARC1981
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CYPOR Rabbit mAb (CAB5032) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
