The POPDC3 Polyclonal Antibody (PACO57520) is a valuable tool for researchers studying POPDC3, a membrane protein involved in various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting and immunofluorescence applications. By targeting the POPDC3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component in studies of cell biology and signal transduction pathways.POPDC3, also known as Popeye domain-containing protein 3, is known to play a role in cardiac and skeletal muscle development, as well as in the regulation of ion channel activity.
Its involvement in these crucial physiological processes makes it a promising target for research in cardiovascular diseases, muscular disorders, and developmental biology. Investigating the function of POPDC3 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies.
Antibody Name:
POPDC3 Antibody (PACO57520)
Antibody SKU:
PACO57520
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Popeye domain-containing protein 3 protein (130-291AA)
Immunofluorescence staining of Hela cells with PACO57520 at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.
Synonyms:
Popeye domain-containing protein 3 (Popeye protein 3), POPDC3, POP3
UniProt Protein Function:
POPDC3: May play an important role in heart development. Belongs to the popeye family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6q21Cellular Component: integral component of membraneMolecular Function: cAMP bindingBiological Process: regulation of membrane potential
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in these tissues during development. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2008]
