The POP1 Polyclonal Antibody (CAB5961) is a valuable tool for research involving POP1, a protein implicated in ribosomal biogenesis and pre-rRNA processing. This antibody, produced in rabbits, exhibits high reactivity with human and mouse samples, making it suitable for a range of research applications, including Western blotting and immunofluorescence.POP1 is a crucial component of the Pescadillo complex, which plays a key role in ribosome biogenesis and RNA processing. Dysregulation of POP1 has been linked to various developmental disorders and diseases, including cancer.
By targeting POP1 with this antibody, researchers can gain insights into its function and potential therapeutic implications in these contexts.By utilizing the POP1 Polyclonal Antibody, researchers can further elucidate the molecular mechanisms underlying ribosomal biogenesis and RNA processing, paving the way for future advancements in biomedicine and drug discovery. Its specificity and sensitivity make it an indispensable tool for advancing our understanding of POP1 in health and disease.
Product Name:
POP1 Rabbit Polyclonal Antibody
SKU:
CAB5961
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human POP1 (NP_055844.2).
This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10940
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using POP1 antibody (CAB5961) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
