The PON3 Polyclonal Antibody (CAB16418) is a valuable tool for researchers studying the PON3 protein, an enzyme involved in antioxidant defense and cardiovascular health. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications.PON3, part of the paraoxonase family of enzymes, plays a crucial role in protecting against oxidative stress and lipid peroxidation, contributing to overall cardiovascular health. Dysregulation of PON3 has been linked to various diseases, including atherosclerosis and cardiovascular disorders, highlighting the importance of studying this enzyme in medical research.
By using the PON3 Polyclonal Antibody, researchers can effectively detect and analyze PON3 protein levels in different cell types, allowing for a better understanding of its function and potential therapeutic implications. This antibody serves as a valuable tool for studies in cardiovascular biology, oxidative stress, and related fields, providing insight into the role of PON3 in health and disease.
Product Name:
PON3 Rabbit Polyclonal Antibody
SKU:
CAB16418
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_000931.1).
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.
Purification Method:
Affinity purification
Gene ID:
5446
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PON3 Rabbit pAb (CAB16418) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
