The POMP Polyclonal Antibody (CAB9067) is a valuable tool for researchers studying the role of POMP (Proteasome Maturation Protein) in cell biology and protein degradation processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.POMP is essential for the maturation of the 20S core particle of the proteasome, the cellular machinery responsible for degrading damaged or unwanted proteins. Dysregulation of POMP has been linked to various diseases, including neurodegenerative disorders and cancer. By targeting the POMP protein, researchers can better understand the mechanisms underlying protein degradation and potentially develop novel therapeutic strategies for these conditions.
With its specificity and sensitivity, the POMP Polyclonal Antibody (CAB9067) enables accurate detection and analysis of POMP in different cell types and experimental settings. Its utility in studying protein degradation pathways makes it a valuable asset for those involved in proteasome research, molecular biology, and drug discovery efforts. Gain deeper insights into POMP function and its implications in health and disease with this reliable antibody tool.
Product Name:
POMP Rabbit Polyclonal Antibody
SKU:
CAB9067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human POMP (NP_057016.1).
The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.
Purification Method:
Affinity purification
Gene ID:
51371
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using POMP Rabbit pAb (CAB9067) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
