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POLR3G Antibody (PACO02164)

SKU:
PACO02164
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$383

Description

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POLR3G Antibody (PACO02164)

The POLR3G Polyclonal Antibody (PACO02164) is a research tool designed for investigating the POLR3G protein, a subunit of RNA polymerase III involved in the transcription of various non-coding RNAs. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the POLR3G protein, this antibody enables the detection and analysis of POLR3G in different cell types, making it well-suited for studies in molecular biology and gene regulation.

POLR3G is a crucial component of the RNA polymerase III complex, which transcribes essential non-coding RNAs such as tRNAs and 5S rRNA. Dysregulation of POLR3G expression has been linked to various diseases, including neurodevelopmental disorders and cancer. Investigating the function of POLR3G is essential for understanding its role in gene expression and disease pathogenesis, potentially leading to the development of targeted therapies in the future.

Antibody Name:POLR3G Antibody
Antibody SKU:PACO02164
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human POLR3G.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:POLR3G; DNA-directed RNA polymerase III subunit RPC7; RNA polymerase III subunit C7; DNA-directed RNA polymerase III subunit G; RNA polymerase III 32 kDa subunit; RPC32
UniProt Protein Function:POLR3G: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPC7 RNA polymerase subunit family.Protein type: EC 2.7.7.6; Transcription initiation complex; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; TransferaseChromosomal Location of Human Ortholog: 5q14.3Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nuclear chromatin; nucleoplasmMolecular Function: DNA-directed RNA polymerase activityBiological Process: cell proliferation; positive regulation of innate immune response; positive regulation of interferon type I production; positive regulation of interferon-beta production; transcription initiation from RNA polymerase III promoter
UniProt Protein Details:
NCBI Summary:
UniProt Code:O15318
NCBI GenInfo Identifier:218511818
NCBI Gene ID:10622
NCBI Accession:O15318.2
UniProt Secondary Accession:O15318,A8MTH0
UniProt Related Accession:O15318
Molecular Weight:25,914 Da
NCBI Full Name:DNA-directed RNA polymerase III subunit RPC7
NCBI Synonym Full Names:RNA polymerase III subunit G
NCBI Official Symbol:POLR3G  
NCBI Official Synonym Symbols:RPC7; RPC32  
NCBI Protein Information:DNA-directed RNA polymerase III subunit RPC7
UniProt Protein Name:DNA-directed RNA polymerase III subunit RPC7
UniProt Synonym Protein Names:DNA-directed RNA polymerase III subunit G; RNA polymerase III 32 kDa subunit; RPC32
Protein Family:
UniProt Gene Name:POLR3G  
UniProt Entry Name:RPC7_HUMAN

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