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POLR3E Antibody (PACO06772)

SKU:
PACO06772
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • POLR3E Antibody PACO06772
  • POLR3E Antibody PACO06772
€269
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Description

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POLR3E Antibody (PACO06772)

The POLR3E Polyclonal Antibody (PACO06772) is a valuable tool for research involving POLR3E, a subunit of RNA polymerase III essential for transcription. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications. By targeting the POLR3E protein, researchers can detect and analyze its expression in various cell types, offering insights into transcriptional regulation and potential implications for diseases such as cancer and genetic disorders.

POLR3E is a crucial component of the RNA polymerase III complex, responsible for transcribing small structural RNAs essential for cellular function. Its role in gene expression and regulation makes it an attractive target for investigating transcriptional dysregulation in disease states. By gaining a better understanding of POLR3E dynamics, researchers can uncover novel therapeutic strategies for targeting transcriptional abnormalities in cancer and other disorders.

Antibody Name:POLR3E Antibody (PACO06772)
Antibody SKU:PACO06772
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from the Internal region of human POLR3E.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot analysis of Jurkat K562 cells using POLR3E Polyclonal Antibody.
Product ImageWestern Blot analysis of JK cells using POLR3E Polyclonal Antibody.
Synonyms:POLR3E; KIAA1452; DNA-directed RNA polymerase III subunit RPC5; RNA polymerase III subunit C5; DNA-directed RNA polymerase III 80 kDa polypeptide
UniProt Protein Function:POLR3E: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription initiation complex; EC 2.7.7.6; TransferaseChromosomal Location of Human Ortholog: 16p12.2Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nucleoplasmBiological Process: defense response to virus; gene expression; innate immune response; positive regulation of interferon type I production; RNA elongation from RNA polymerase III promoter; termination of RNA polymerase III transcription; transcription from RNA polymerase III promoter
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9NVU0
NCBI GenInfo Identifier:29428028
NCBI Gene ID:101060521
NCBI Accession:Q9NVU0.1
UniProt Secondary Accession:Q9NVU0,Q9BWF7, Q9H8W8, Q9H907, Q9P276, B4DL24, B4DUP6 H3BT11
UniProt Related Accession:Q9NVU0
Molecular Weight:75,758 Da
NCBI Full Name:DNA-directed RNA polymerase III subunit RPC5
NCBI Synonym Full Names:
NCBI Official Symbol:LOC101060521  
NCBI Official Synonym Symbols:
NCBI Protein Information:DNA-directed RNA polymerase III subunit RPC5
UniProt Protein Name:DNA-directed RNA polymerase III subunit RPC5
UniProt Synonym Protein Names:DNA-directed RNA polymerase III 80 kDa polypeptide
Protein Family:DNA-directed RNA polymerase
UniProt Gene Name:POLR3E  
UniProt Entry Name:RPC5_HUMAN
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