POLR3D Antibody (PACO22314)
- SKU:
- PACO22314
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
POLR3D Antibody (PACO22314)
The POLR3D Polyclonal Antibody (PAC022314) is a valuable tool for researchers studying POLR3D, a key subunit of RNA polymerase III involved in transcription. This antibody, produced in rabbits, exhibits high sensitivity and specificity towards human samples, making it an excellent choice for Western blot applications. By binding specifically to the POLR3D protein, this antibody enables accurate detection and analysis in a variety of cell types, making it essential for studies in molecular biology and gene transcription.
POLR3D is essential for the transcription of genes encoding small RNAs, such as tRNAs and 5S rRNA, playing a crucial role in cellular processes. Dysregulation of POLR3D has been linked to various diseases, making it a promising target for research in areas such as cancer, neurodegenerative disorders, and developmental abnormalities. Understanding the function of POLR3D is vital for unraveling its role in these conditions and exploring potential therapeutic interventions.
| Antibody Name: | POLR3D Antibody (PACO22314) |
| Antibody SKU: | PACO22314 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human RPC4. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from MCF-7 cells, using RPC4 antibody. |
| Background: | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity. |
| Synonyms: | DNA-directed RNA polymerase III subunit RPC4; RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; DNA-directed RNA polymerase III 47 kDa polypeptide; RPC53 |
| UniProt Protein Function: | POLR3D: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: 8q21Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nuclear chromatin; nucleoplasmBiological Process: positive regulation of innate immune response; positive regulation of interferon type I production; positive regulation of interferon-beta production |
| UniProt Protein Details: | |
| NCBI Summary: | This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05423 |
| NCBI GenInfo Identifier: | 29429159 |
| NCBI Gene ID: | 661 |
| NCBI Accession: | P05423.2 |
| UniProt Secondary Accession: | P05423,Q6FI28, Q9BPV7, Q9BPZ1, Q9BXB3 |
| UniProt Related Accession: | P05423 |
| Molecular Weight: | 44,396 Da |
| NCBI Full Name: | DNA-directed RNA polymerase III subunit RPC4 |
| NCBI Synonym Full Names: | RNA polymerase III subunit D |
| NCBI Official Symbol: | POLR3DÂ Â |
| NCBI Official Synonym Symbols: | RPC4; BN51T; RPC53; TSBN51Â Â |
| NCBI Protein Information: | DNA-directed RNA polymerase III subunit RPC4 |
| UniProt Protein Name: | DNA-directed RNA polymerase III subunit RPC4 |
| UniProt Synonym Protein Names: | DNA-directed RNA polymerase III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RPC53 homolog |
| Protein Family: | |
| UniProt Gene Name: | POLR3DÂ Â |
| UniProt Entry Name: | RPC4_HUMAN |
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