The POLR3B Polyclonal Antibody (CAB12660) is a valuable tool for researchers studying RNA polymerase III subunit B (POLR3B) protein. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the POLR3B protein, this antibody enables researchers to detect and analyze POLR3B in various cell types, making it an ideal choice for studies in molecular biology and genetics.POLR3B is a key component of RNA polymerase III, which plays a crucial role in transcription and gene expression. Mutations in the POLR3B gene have been associated with a range of genetic diseases, including neurological disorders and developmental delays.
By studying POLR3B, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially uncover new therapeutic targets.The POLR3B Polyclonal Antibody is an essential tool for researchers conducting investigations into the functions of POLR3B in health and disease. Its high specificity and sensitivity make it a reliable choice for studies aiming to unravel the complexities of gene expression regulation and identify potential therapeutic interventions.
Product Name:
POLR3B Rabbit Polyclonal Antibody
SKU:
CAB12660
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 680-900 of human POLR3B (NP_060552.4).
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
55703
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using POLR3B Rabbit pAb (CAB12660) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
