UniProt Protein Function: | Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. |
NCBI Summary: | This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013] |
UniProt Code: | Q6EEV4 |
NCBI GenInfo Identifier: | 70166832 |
NCBI Gene ID: | 81488 |
NCBI Accession: | NP_001018112.1 |
UniProt Secondary Accession: | Q6EEV4,Q6EER8, Q6EES2, Q6EEV3, Q6EF00, Q6EF01, Q6EF02 Q6EF46, Q6EFN8, Q6EM48, Q6K046, Q6K050, |
UniProt Related Accession: | P0CAP2,Q6EEV4 |
Molecular Weight: | 15,131 Da |
NCBI Full Name: | protein GRINL1A isoform 2 |
NCBI Synonym Full Names: | RNA polymerase II subunit M |
NCBI Official Symbol: | POLR2MÂ Â |
NCBI Official Synonym Symbols: | GCOM1; Gdown; Gdown1; GRINL1AÂ Â |
NCBI Protein Information: | protein GRINL1A |
UniProt Protein Name: | DNA-directed RNA polymerase II subunit GRINL1A |
UniProt Synonym Protein Names: | DNA-directed RNA polymerase II subunit M; Glutamate receptor-like protein 1A |
Protein Family: | DNA-directed RNA polymerase |
UniProt Gene Name: | POLR2MÂ Â |