The POLR1D Polyclonal Antibody (PACO43637) is a valuable tool for researchers studying the POLR1D protein, a critical component of RNA polymerase I that is essential for ribosomal RNA synthesis. This antibody, generated in rabbits, demonstrates strong reactivity with human samples and is suitable for Western blot applications. By specifically targeting the POLR1D protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in molecular biology and cancer research.POLR1D plays a crucial role in ribosome biogenesis and protein synthesis, making it a promising target for understanding diseases like cancer where dysregulation of these processes can occur.
By studying the function of POLR1D, researchers can gain insights into how disruptions in ribosomal RNA synthesis contribute to tumorigenesis and potentially identify new therapeutic strategies for combating cancer progression. The PACO43637 antibody offers a reliable tool for exploring the role of POLR1D in these disease contexts and advancing scientific knowledge in the field of molecular biology.
Antibody Name:
POLR1D Antibody (PACO43637)
Antibody SKU:
PACO43637
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC2 protein (1-133AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human skin tissue using PACO43637 at dilution of 1:100.
Background:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.
Synonyms:
DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19), POLR1D
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
