The POLR1D Polyclonal Antibody (PAC043636) is a valuable tool for researchers studying POLR1D, a subunit of RNA polymerase I involved in transcription. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the POLR1D protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal choice for studies in molecular biology and gene expression.POLR1D plays a crucial role in the transcription of ribosomal RNA, making it essential for the synthesis of ribosomes and ultimately protein production. Dysregulation of POLR1D has been linked to diseases such as cancer, developmental disorders, and neurodegenerative conditions.
By investigating the function and regulation of POLR1D, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the POLR1D Polyclonal Antibody is a reliable tool for researchers interested in exploring the role of POLR1D in gene expression and disease processes. Its specificity and sensitivity make it well-suited for a variety of research applications, providing valuable data for advancing our understanding of transcriptional regulation and its implications for human health.
Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC2 protein (1-133AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot. All lanes: DNA-directed RNA polymerases I and III subunit RPAC2 antibody at 10µg/ml + Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 16, 15 kDa. Observed band size: 16 kDa.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO43636 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skin tissue using PACO43636 at dilution of 1:100.
Background:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.
Synonyms:
DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19), POLR1D
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
