The POLR1C Polyclonal Antibody (CAB0269) is specifically designed for research involving POLR1C, a subunit of RNA polymerase I involved in the transcription of ribosomal RNA. The antibody, generated in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.POLR1C is a key component of the RNA polymerase I complex, essential for the synthesis of ribosomal RNA and protein translation. Dysregulation of POLR1C has been associated with various diseases, including cancer and developmental disorders.
As such, studying the function and expression of POLR1C can provide valuable insights into these conditions and potential therapeutic targets.The POLR1C Polyclonal Antibody enables the detection and analysis of POLR1C in different cell types and tissues, making it an ideal tool for researchers in the fields of molecular biology, biochemistry, and oncology. Understanding the role of POLR1C in gene expression and disease pathology is essential for advancing our knowledge of cellular processes and developing targeted treatments in the future.
Product Name:
POLR1C Rabbit Polyclonal Antibody
SKU:
CAB0269
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human POLR1C (NP_976035.1).
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9533
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using POLR1C Rabbit pAb (CAB0269) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
