The POLR1A Polyclonal Antibody (PACO11351) is specifically designed for researchers studying POLR1A, a key enzyme involved in RNA transcription. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blotting applications. By binding to the POLR1A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in molecular biology and gene expression regulation.POLR1A is an essential component of the RNA polymerase I complex, responsible for transcribing ribosomal RNA genes. Dysregulation of POLR1A has been linked to various diseases, including cancer and developmental disorders.
By studying the function and regulation of POLR1A, researchers can gain valuable insights into cellular processes and potential therapeutic targets for disease treatment.In conclusion, the PACO11351 Polyclonal Antibody provides a reliable and specific tool for investigating the role of POLR1A in various biological processes. Its high reactivity and validated performance make it an ideal choice for researchers interested in elucidating the molecular mechanisms underlying gene expression and disease development.
polymerase (RNA) I polypeptide A, 194kDa;POLR1A;DKFZp586M0122;FLJ21915;MGC87965;RPA1;RPO1-4 ;RPA194
UniProt Protein Function:
POLR1A: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Belongs to the RNA polymerase beta' chain family.Protein type: Nucleolus; Transcription initiation complex; Nucleotide Metabolism - purine; Transferase; EC 2.7.7.6; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: 2p11.2Cellular Component: cytoplasm; DNA-directed RNA polymerase I complex; nucleolus; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoterDisease: Acrofacial Dysostosis, Cincinnati Type
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]
