The Polk Polyclonal Antibody (CAB12052) is a crucial tool for research involving Polk, a protein involved in regulating cellular processes, particularly in the context of cancer biology. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. By binding specifically to the Polk protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for studies in oncology and cell biology.Polk, also known as DNA polymerase kappa, is involved in DNA damage repair and replication, playing a vital role in maintaining genomic stability.
Dysregulation of Polk has been implicated in the development and progression of various cancers, making it a promising target for cancer research and therapy development. Understanding the function and regulation of Polk is essential for unraveling its role in tumorigenesis and identifying potential strategies for cancer treatment.Overall, the Polk Polyclonal Antibody (CAB12052) provides researchers with a reliable tool for investigating the function of Polk in cancer biology, offering valuable insights that could lead to the development of novel therapeutic approaches for cancer treatment.
Product Name:
POLK Rabbit Polyclonal Antibody
SKU:
CAB12052
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human POLK (NP_057302.1).
This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients.
Purification Method:
Affinity purification
Gene ID:
51426
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using POLK Rabbit pAb (CAB12052) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
