The Poliovirus Receptor Polyclonal Antibody (CAB5753) is a valuable tool for researchers studying the poliovirus receptor (PVR), a cell surface protein involved in viral entry and infection. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the PVR protein, this antibody enables detection and analysis of PVR expression in various cell types, making it ideal for studies in virology and infectious disease research.The PVR, also known as CD155, plays a crucial role in facilitating the entry of poliovirus into host cells.
Understanding the mechanisms of PVR-mediated viral infection is essential for developing antiviral strategies and vaccines against poliovirus and related viruses. By studying the interaction between the poliovirus receptor and the virus, researchers can gain insights into the pathogenesis of viral infections and identify potential targets for therapeutic intervention.Overall, the Poliovirus Receptor Polyclonal Antibody (CAB5753) offers researchers a reliable tool for investigating the role of PVR in viral infections, providing valuable insights into the molecular mechanisms of viral entry and pathogenesis.
Product Name:
CD155/PVR Rabbit Polyclonal Antibody
SKU:
CAB5753
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-345 of human CD155/PVR (NP_006496.4?).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
70kDa
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5817
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD155/PVR antibody (CAB5753) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
