The DNA Polymerase iota Polyclonal Antibody (CAB1942) is a valuable tool for researchers studying DNA polymerase iota, a specialized enzyme involved in DNA replication and repair processes. This antibody, produced in rabbits, is highly specific for detecting DNA polymerase iota in human samples, making it ideal for use in Western blot applications.DNA polymerase iota is known for its unique ability to replicate damaged DNA, making it a key player in maintaining genomic stability and preventing mutations. Its role in DNA repair processes is crucial for cell survival and overall genome integrity.
By targeting DNA polymerase iota with this antibody, researchers can study its function in various biological contexts, including cancer research and understanding mechanisms of DNA damage and repair.Overall, the DNA Polymerase iota Polyclonal Antibody (CAB1942) is a valuable tool for investigating the role of DNA polymerase iota in genome maintenance and cellular processes, providing insights that can potentially lead to the development of novel therapeutics targeting DNA repair pathways.
Product Name:
POLI Rabbit Polyclonal Antibody
SKU:
CAB1942
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human POLI (NP_009126.2).
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion.
Purification Method:
Affinity purification
Gene ID:
11201
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using POLI antibody (CAB1942) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
