DNA Polymerase gamma Rabbit Polyclonal Antibody (CAB8451)
- SKU:
- CAB8451
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | DNA Polymerase gamma Rabbit Polyclonal Antibody |
SKU: | CAB8451 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of human DNA Polymerase gamma (NP_002684.1). |
Sequence: | QQDV MARA CLQK LKGT TELL PKRP QHLP GHPG WYRK LCPR LDDP AWTP GPSL LSLQ MRVT PKLM ALTW DGFP LHYS ERHG WGYL VPGR RDNL AKLP TGTT LESA GVVC PYRA IESL YRKH CLEQ GKQQ LMPQ EAGL AEEF LLTD NSAI WQTV EELD YLEV EAEA KMEN LRAA VPGQ PLAL T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | PEO; MDP1; SCAE; MIRAS; POLG1; POLGA; SANDO; MTDPS4A; MTDPS4B; DNA Polymerase gamma |
Positive Sample: | 293F,Jurkat,Mouse placenta,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion, Mitochondrion matrix, mitochondrion nucleoid. |
Calculated MW: | 140kDa |
Observed MW: | 140kDa |
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5428 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |