POLE4 Polyclonal Antibody
- SKU:
- CAB24516
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
POLE4 Polyclonal Antibody (CAB24516)
The Pole4 Polyclonal Antibody is a valuable tool for researchers studying the Pole4 protein, a key player in DNA replication and repair processes. This antibody, generated in rabbits, is highly specific for detecting Pole4 in human samples and has been validated for use in Western blot applications. By binding to the Pole4 protein, researchers can easily visualize and analyze its expression in various cell types, making it an essential tool for studies in genetics and cancer biology.Pole4 is essential for maintaining genomic stability and proper functioning of the cell cycle, making it a crucial target for research into cancer development and progression.
By understanding the role of Pole4 in DNA replication and repair, researchers can gain insights into mechanisms underlying tumorigenesis and potentially identify novel therapeutic targets for cancer treatment. The Pole4 Polyclonal Antibody provides researchers with a reliable tool to advance their understanding of Pole4 function and its implications in cancer biology.
| Product Name: | POLE4 Polyclonal Antibody |
| Product Code: | CAB24516 |
| Reactivity: | Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse liver |
| Cellular Location: | Nucleus |
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human POLE4 (NP_063949.2). |
| Sequence: | MAAAA AAGSG TPREE EGPAG EAAAS QPQAP TSVPG ARLSR LPLAR VKALV KADPD VTLAG QEAIF ILARA AELFV ETIAK DAYCC AQQGK RKTLQ RRDLD |
| Synonyms: | POLE4, YHHQ1, p12, DNA polymerase epsilon subunit 4 |
| Calculated MW: | 12kDa |
| Observed MW: | 15kDa |
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