POLDIP3 Antibody (PACO22507)
- SKU:
- PACO22507
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
POLDIP3 Antibody (PACO22507)
The POLDIP3 Polyclonal Antibody (PAC022507) is a powerful tool for researchers studying POLDIP3, a protein involved in DNA damage response and cell cycle regulation. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications. By binding to the POLDIP3 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component for investigations in molecular biology and cancer research.
POLDIP3, also known as polymerase delta-interacting protein 3, plays a crucial role in maintaining genomic stability and controlling cell proliferation. Dysregulation of POLDIP3 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. By understanding the function of POLDIP3, researchers can uncover new insights into disease mechanisms and develop innovative treatment strategies aimed at restoring cellular homeostasis.
| Antibody Name: | POLDIP3 Antibody (PACO22507) |
| Antibody SKU: | PACO22507 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human POLDIP3. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from RAW264.7 cells, using POLDIP3 antibody. |
| Background: | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex. |
| Synonyms: | 46 kDa DNA polymerase delta interaction protein; KIAA1649; p46; PDIP3; PDIP46 |
| UniProt Protein Function: | SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck Molecular Function:protein binding; nucleotide binding Biological Process: poly(A)+ mRNA export from nucleus; positive regulation of translation |
| NCBI Summary: | This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9BY77 |
| NCBI GenInfo Identifier: | 50403796 |
| NCBI Gene ID: | 84271 |
| NCBI Accession: | Q9BY77.2 |
| UniProt Secondary Accession: | Q9BY77,Q009A7, Q5H972, Q6PGN6, Q7Z6Z0, Q9NSP5, Q9NSP6 A8K6F8, A8K6V9, |
| UniProt Related Accession: | Q9BY77 |
| Molecular Weight: | 421 |
| NCBI Full Name: | Polymerase delta-interacting protein 3 |
| NCBI Synonym Full Names: | polymerase (DNA-directed), delta interacting protein 3 |
| NCBI Official Symbol: | POLDIP3Â Â |
| NCBI Official Synonym Symbols: | SKAR; PDIP46Â Â |
| NCBI Protein Information: | polymerase delta-interacting protein 3; RNA-binding protein P46; S6K1 Aly/REF-like target; 46 kDa DNA polymerase delta interaction protein |
| UniProt Protein Name: | Polymerase delta-interacting protein 3 |
| UniProt Synonym Protein Names: | 46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR |
| Protein Family: | Polymerase delta-interacting protein |
| UniProt Gene Name: | POLDIP3Â Â |
| UniProt Entry Name: | PDIP3_HUMAN |
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