null

POLDIP3 Antibody (PACO11345)

SKU:
PACO11345
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551

Description

system_update_altDatasheetsystem_update_altMSDS

POLDIP3 Antibody (PACO11345)

The POLDIP3 Polyclonal Antibody (PACO11345) is a valuable tool for researchers studying the POLDIP3 protein, which is involved in various cellular processes such as DNA replication and repair. This antibody, produced using rabbits, is highly specific to human samples and has been validated for use in Western blot applications.POLDIP3, also known as polymerase delta interacting protein 3, plays a crucial role in maintaining genomic stability and integrity by interacting with key enzymes involved in DNA synthesis.

Dysregulation of POLDIP3 has been linked to various diseases, including cancer and genetic disorders.By utilizing the POLDIP3 Polyclonal Antibody, researchers can accurately detect and analyze POLDIP3 expression in different cell types, providing insights into its function and potential implications in disease pathology. This antibody is an essential tool for studies in molecular biology, oncology, and genetic research aiming to understand the role of POLDIP3 in health and disease.

Antibody Name:POLDIP3 Antibody (PACO11345)
Antibody SKU:PACO11345
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human POLDIP3
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:polymerase (DNA-directed), delta interacting protein 3;POLDIP3;KIAA1649;PDIP46;SKAR ;
UniProt Protein Function:SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck

Molecular Function:protein binding; nucleotide binding

Biological Process: poly(A)+ mRNA export from nucleus; positive regulation of translation

NCBI Summary:This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9BY77
NCBI GenInfo Identifier:50403796
NCBI Gene ID:84271
NCBI Accession:Q9BY77.2
UniProt Secondary Accession:Q9BY77,Q009A7, Q5H972, Q6PGN6, Q7Z6Z0, Q9NSP5, Q9NSP6 A8K6F8, A8K6V9,
UniProt Related Accession:Q9BY77
Molecular Weight:421
NCBI Full Name:Polymerase delta-interacting protein 3
NCBI Synonym Full Names:polymerase (DNA-directed), delta interacting protein 3
NCBI Official Symbol:POLDIP3  
NCBI Official Synonym Symbols:SKAR; PDIP46  
NCBI Protein Information:polymerase delta-interacting protein 3; RNA-binding protein P46; S6K1 Aly/REF-like target; 46 kDa DNA polymerase delta interaction protein
UniProt Protein Name:Polymerase delta-interacting protein 3
UniProt Synonym Protein Names:46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR
Protein Family:Polymerase delta-interacting protein
UniProt Gene Name:POLDIP3  
UniProt Entry Name:PDIP3_HUMAN

Related Products