POLDIP3 Antibody (PACO05509)
- SKU:
- PACO05509
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
POLDIP3 Antibody (PACO05509)
The POLDIP3 Polyclonal Antibody (PACO05509) is a valuable tool for researchers studying POLDIP3, a protein known for its involvement in DNA replication and repair processes. This antibody, produced in rabbits, exhibits high specificity for human samples and is recommended for use in Western blotting applications. By binding to the POLDIP3 protein, researchers can accurately detect and analyze its expression in various cell types, making it well-suited for studies in molecular biology and cancer research.POLDIP3, also known as polymerase delta interacting protein 3, plays a crucial role in maintaining genomic stability and ensuring accurate DNA replication.
Its functions are implicated in cellular responses to DNA damage and replication stress, making it an attractive target for investigations into oncogenesis and genetic diseases. Understanding the mechanisms by which POLDIP3 operates is essential for developing targeted therapies aimed at enhancing DNA repair and preventing mutations that lead to cancer and other genetic disorders.
| Antibody Name: | POLDIP3 Antibody (PACO05509) |
| Antibody SKU: | PACO05509 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human POLDIP3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | POLDIP3; KIAA1649; PDIP46; Polymerase delta-interacting protein 3; 46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR |
| UniProt Protein Function: | SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck Molecular Function:protein binding; nucleotide binding Biological Process: poly(A)+ mRNA export from nucleus; positive regulation of translation |
| NCBI Summary: | This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9BY77 |
| NCBI GenInfo Identifier: | 50403796 |
| NCBI Gene ID: | 84271 |
| NCBI Accession: | Q9BY77.2 |
| UniProt Secondary Accession: | Q9BY77,Q009A7, Q5H972, Q6PGN6, Q7Z6Z0, Q9NSP5, Q9NSP6 A8K6F8, A8K6V9, |
| UniProt Related Accession: | Q9BY77 |
| Molecular Weight: | 421 |
| NCBI Full Name: | Polymerase delta-interacting protein 3 |
| NCBI Synonym Full Names: | polymerase (DNA-directed), delta interacting protein 3 |
| NCBI Official Symbol: | POLDIP3Â Â |
| NCBI Official Synonym Symbols: | SKAR; PDIP46Â Â |
| NCBI Protein Information: | polymerase delta-interacting protein 3; RNA-binding protein P46; S6K1 Aly/REF-like target; 46 kDa DNA polymerase delta interaction protein |
| UniProt Protein Name: | Polymerase delta-interacting protein 3 |
| UniProt Synonym Protein Names: | 46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR |
| Protein Family: | Polymerase delta-interacting protein |
| UniProt Gene Name: | POLDIP3Â Â |
| UniProt Entry Name: | PDIP3_HUMAN |
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