The POLD4 Polyclonal Antibody (CAB8506) is a valuable tool for researchers studying POLD4, a protein involved in DNA replication and repair processes. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the POLD4 protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating studies in genetics, oncology, and molecular biology.POLD4, also known as DNA polymerase delta subunit 4, plays a crucial role in maintaining genomic stability and integrity, making it an important target for research into cancer and genetic disorders.
Understanding the function and regulation of POLD4 can provide insights into mechanisms of DNA replication and repair, as well as potential therapeutic strategies for diseases associated with genomic instability.Overall, the POLD4 Polyclonal Antibody (CAB8506) offers researchers a reliable tool for investigating the role of POLD4 in various cellular processes and disease states, ultimately contributing to advancements in biomedical research and drug development.
Product Name:
POLD4 Rabbit Polyclonal Antibody
SKU:
CAB8506
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-107 of human POLD4 (NP_066996.3).
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
57804
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of MCF-7 cells, using POLD4 antibody (CAB8506) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
