The POLD3 Polyclonal Antibody (CAB7243) is a vital tool for researchers studying POLD3, a key protein involved in DNA replication and repair processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for various research applications, including Western blot analysis. By binding to the POLD3 protein, this antibody enables precise detection and analysis in different cell types, providing valuable insights for studies in molecular biology and cancer research.POLD3 is a crucial component of the DNA polymerase delta complex, essential for accurate and efficient DNA replication.
Dysregulation of POLD3 has been linked to genomic instability and cancer development, highlighting its significance in maintaining genome integrity. By investigating the function and regulation of POLD3, researchers can uncover potential targets for cancer therapy and improve our understanding of DNA damage repair mechanisms.Overall, the POLD3 Polyclonal Antibody is a valuable resource for scientists exploring the role of POLD3 in various biological processes, offering reliable and reproducible results for advancing research in genetics and oncology.
Product Name:
POLD3 Rabbit Polyclonal Antibody
SKU:
CAB7243
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 197-466 of human POLD3 (NP_006582.1).
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
10714
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using POLD3 Rabbit pAb (CAB7243) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
