The POLD1 Rabbit Monoclonal Antibody (CAB4218) is a high-quality antibody designed for research involving POLD1, a DNA polymerase enzyme essential for DNA replication and repair processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.POLD1 plays a crucial role in maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer development. Dysregulation of POLD1 has been implicated in various cancer types, making it a potential target for cancer therapy research.
This antibody enables the detection and analysis of POLD1 protein expression in different cell types, providing valuable insights into its function and potential as a therapeutic target in cancer treatment.By utilizing the POLD1 Rabbit Monoclonal Antibody (CAB4218), researchers can further explore the role of POLD1 in DNA replication and repair mechanisms, as well as its implications in cancer biology. This antibody is a valuable tool for studies in oncology, genetics, and molecular biology, offering new avenues for understanding and potentially targeting POLD1-related pathways in cancer research.
Product Name:
POLD1 Rabbit Monoclonal Antibody
SKU:
CAB4218
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1000-1107 of human POLD1 (P28340).
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
Purification Method:
Affinity purification
Gene ID:
5424
Clone Number:
ARC0930
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using POLD1 Rabbit mAb (CAB4218) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
