POGZ Antibody (PACO29046)
- SKU:
- PACO29046
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
POGZ Antibody (PACO29046)
The POGZ Polyclonal Antibody (PACO29046) is a valuable tool for researchers studying the POGZ protein, which is known to play a key role in chromatin remodeling and gene regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications such as Western blot and immunohistochemistry.POGZ, also known as Pogo Transposable Element Derived Protein, is essential for proper genomic organization and maintenance of cell viability.
Dysregulation of POGZ has been implicated in various developmental disorders and cancers, making it an attractive target for therapeutic interventions.By using the POGZ Polyclonal Antibody, researchers can effectively detect and study the expression of POGZ in different cell types and tissues, furthering our understanding of its role in health and disease. This antibody is a valuable tool for investigations in genetics, oncology, and developmental biology.
| Antibody Name: | POGZ Antibody (PACO29046) |
| Antibody SKU: | PACO29046 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Pogo transposable element with ZNF domain protein (1-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO29046 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO29046 at dilution of 1:100. |
| Background: | Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. |
| Synonyms: | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635), POGZ, KIAA0461 SUHW5 ZNF280E ZNF635 |
| UniProt Protein Function: | POGZ: a transposable element with a zinc-finger (ZNF) domain. Interacts with the Sp1 transcription factor (SP1). Four alternatively spliced isoforms have been described.Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factorChromosomal Location of Human Ortholog: 1q21.3Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleusMolecular Function: DNA binding; metal ion binding; protein bindingBiological Process: cell division; kinetochore assembly; mitotic sister chromatid cohesionDisease: Mental Retardation, Autosomal Dominant 37 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q7Z3K3 |
| NCBI GenInfo Identifier: | 46397390 |
| NCBI Gene ID: | 23126 |
| NCBI Accession: | NP_055915 |
| UniProt Secondary Accession: | Q7Z3K3 |
| UniProt Related Accession: | Q7Z3K3 |
| Molecular Weight: | 155kDa |
| NCBI Full Name: | pogo transposable element with ZNF domain isoform 1 |
| NCBI Synonym Full Names: | pogo transposable element derived with ZNF domain |
| NCBI Official Symbol: | POGZ |
| NCBI Official Synonym Symbols: | MRD37; WHSUS; ZNF635; ZNF280E; ZNF635m |
| NCBI Protein Information: | pogo transposable element with ZNF domain |
| UniProt Protein Name: | Pogo transposable element with ZNF domain |
| UniProt Synonym Protein Names: | Suppressor of hairy wing homolog 5; Zinc finger protein 280E; Zinc finger protein 635 |
| Protein Family: | Pogo transposable element with ZNF domain |
| UniProt Gene Name: | POGZ |
| UniProt Entry Name: |
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