The POF1B Polyclonal Antibody (CAB17775) is a valuable tool for researchers studying POF1B, a protein involved in ovarian function and fertility. This rabbit-raised antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the POF1B protein, this antibody enables the detection and analysis of POF1B in various cell types, making it an excellent choice for studies in reproductive biology and infertility research.POF1B is a key player in ovarian development and function, making it a crucial target for investigating disorders related to female fertility.
Understanding the role of POF1B can provide insights into conditions such as premature ovarian failure and polycystic ovary syndrome, offering potential avenues for therapeutic interventions and reproductive health treatments.Overall, the POF1B Polyclonal Antibody (CAB17775) provides researchers with a reliable tool for exploring the function and regulation of POF1B in relation to female reproductive health, offering new possibilities for advancing our understanding of ovarian biology and fertility.
Product Name:
POF1B Rabbit Polyclonal Antibody
SKU:
CAB17775
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 330-560 of human POF1B (NP_079197.3).
Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.
Purification Method:
Affinity purification
Gene ID:
79983
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat kidney, using POF1B Rabbit pAb (CAB17775) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
