POF1B Rabbit Polyclonal Antibody (CAB17775)
- SKU:
- CAB17775
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | POF1B Rabbit Polyclonal Antibody |
SKU: | CAB17775 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-560 of human POF1B (NP_079197.3). |
Sequence: | LVLS TFSN IREE LGHL QNDM TSLE NDKM RLEK DLSF KDTQ LKEY EELL ASVR ANNH QQQQ GLQD SSSK CQAL EENN LSLR HTLS DMEY RLKE LEYC KRNL EQEN QNLR MQVS ETCT GPML QAKM DEIG NHYT EMVK NLRM EKDR EICR LRSQ LNQY HKDV SKRE GSCS DFQF KLHE LTSL LEEK DSLI KRQS EELS KLRQ EIYS SHNQ PSTG GRTT ITTK KYRT QYPI LGL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | POF; POF2B; POF1B |
Positive Sample: | Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | adherens junction, bicellular tight junction, desmosome |
Calculated MW: | 68kDa |
Observed MW: | 85kDa |
Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.
Purification Method: | Affinity purification |
Gene ID: | 79983 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |