The POC5 Antibody (PACO60280) is a valuable tool for researchers studying the POC5 protein, found in the centrosome, a crucial organelle involved in cell division and organization. This polyclonal antibody, developed and validated for use in various research applications, is highly specific and sensitive, making it ideal for detecting and analyzing POC5 in different cell types.POC5 plays a critical role in centrosome function, contributing to the regulation of cell cycle progression and chromosome segregation. Dysregulation of POC5 has been linked to genetic disorders and cancer development, making it a promising target for further investigation in the field of oncology and molecular biology.
By using the POC5 Antibody (PACO60280), researchers can gain insights into the function and regulation of the POC5 protein, advancing our understanding of centrosome biology and its relevance to human health and disease. This antibody holds great potential for uncovering new therapeutic targets and developing novel treatments for a range of medical conditions.
Antibody Name:
POC5 Antibody (PACO60280)
Antibody SKU:
PACO60280
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Centrosomal protein POC5 protein (373-485AA)
IHC image of PACO60280 diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Essential for the assembly of the distal half of centrioles, required for centriole elongation.
Synonyms:
Centrosomal protein POC5 (Protein of centriole 5) (hPOC5), POC5, C5orf37
UniProt Protein Function:
POC5: Essential for the assembly of the distal half of centrioles, required for centriole elongation. Belongs to the POC5 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 5q13.3Cellular Component: centrosomeMolecular Function: protein binding
