PNPO Rabbit Polyclonal Antibody (CAB18495)
- SKU:
- CAB18495
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PNPO Rabbit Polyclonal Antibody |
SKU: | CAB18495 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human PNPO (NP_060599.1). |
Sequence: | MTCW LRGV TATF GRPA EWPG YLSH LCGR SAAM DLGP MRKS YRGD REAF EETH LTSL DPVK QFAA WFEE AVQC PDIG EANA MCLA TCTR DGKP SARM LLLK GFGK DGFR FFTN FESR KGKE LDSN PFAS LVFY WEPL NRQV RVEG PVKK LPEE EAEC YFHS RPKS SQIG AVVS HQSS VIPD REYL RKKN EELE QLYQ DQEV PKPK SWGG YVLY PQVM EFWQ GQTN RLHD RIVF RRGL PTGD SPLG PMTH RGEE DWLY ERLA P |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PDXPO; HEL-S-302; PNPO |
Positive Sample: | HepG2,293T,Mouse brain,Mouse kidney,Mouse liver,Rat brain,Rat kidney,Rat liver |
Cellular Localization: | cytosol |
Calculated MW: | 30kDa |
Observed MW: | 30kDa |
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.
Purification Method: | Affinity purification |
Gene ID: | 55163 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |