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PNPO Monoclonal Antibody [PAT2C7AT] (CPAB0112)

SKU:
CPAB0112
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT2C7AT
Applications:
WB
ELISA
€149
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Description

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PNPO Monoclonal Antibody [PAT2C7AT] (CPAB0112)

The PNPO Polyclonal Antibody (CPAB0112) is an essential tool for researchers studying PNPO, an enzyme involved in vitamin B6 metabolism. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By binding specifically to the PNPO protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in metabolism, genetic disorders, and neurological diseases.PNPO plays a crucial role in converting vitamin B6 into its active form, pyridoxal 5'-phosphate, which is essential for numerous biological processes including amino acid metabolism and neurotransmitter synthesis.

Disruption of PNPO function has been linked to various disorders such as epilepsy, developmental delay, and neurodegenerative diseases. Investigating the role of PNPO using this antibody could lead to a better understanding of these conditions and potentially aid in the development of targeted therapies.

Product Name:PNPO Antibody
Product Sku:CPAB0112
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PNPO mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PNPO amino acids 57-261 purified from Ecoli.
Clone:PAT2C7AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:PNPO antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Pyridoxine-5'-phosphate oxidase (PNPO) is the rate-limiting enzyme in vitamin B6 synthesis. Vitamin B6 (Pyridoxal 5-prime-phosphate or PLP) is vital for normal cellular function, and some cancer cells have notable differences in vitamin B6 metabolism compared to their normal counterparts.Vitamin B6 is an essential co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in the PNPO gene result in PNPO deficiency, a form of neonatal epileptic encephalopathy.
Synonyms:Pyridoxine-5'-phosphate oxidase, Pyridoxamine-phosphate oxidase, PNPO, PDXPO, FLJ10535.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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