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PNPLA8 Antibody (PACO22216)

SKU:
PACO22216
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€419

Description

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PNPLA8 Antibody (PACO22216)

The PNPLA8 Polyclonal Antibody (PACO22216) is a valuable tool for researchers studying PNPLA8, a protein involved in lipid metabolism and cellular homeostasis. This antibody, produced in rabbits, specifically targets the PNPLA8 protein in human samples, allowing for precise detection and analysis in Western blot applications.PNPLA8, also known as adiponutrin, is a key regulator of lipid droplet dynamics and triglyceride metabolism.

Its dysregulation has been associated with various metabolic disorders, making it a promising target for research in obesity, diabetes, and cardiovascular diseases. By utilizing the PNPLA8 Polyclonal Antibody, researchers can further investigate the role of PNPLA8 in these conditions and potentially uncover new therapeutic strategies.

Antibody Name:PNPLA8 Antibody (PACO22216)
Antibody SKU:PACO22216
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from internal of human PNPLA8.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from HeLa cells, A549 cells and HUVEC cells, using PNPLA8 antibody.
Background:Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.
Synonyms:calcium-independent phospholipase A2-gamma; EC 3.1.1.5; intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; patatin-like phospholipase domain-containing protein 8
UniProt Protein Function:PNPLA8: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; EC 3.1.1.5; Phospholipase; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 7q31Cellular Component: endoplasmic reticulum membrane; intracellular; membrane; peroxisomal membrane; peroxisomeMolecular Function: calcium-independent phospholipase A2 activity; phospholipase A2 activityBiological Process: arachidonic acid metabolic process; arachidonic acid secretion; cell death; fatty acid metabolic process; linoleic acid metabolic process; phosphatidylethanolamine catabolic process; prostaglandin biosynthetic processDisease: Mitochondrial Myopathy With Lactic Acidosis
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]
UniProt Code:Q9NP80
NCBI GenInfo Identifier:74734299
NCBI Gene ID:50640
NCBI Accession:Q9NP80.1
UniProt Secondary Accession:Q9NP80,O95035, Q8N3I3, Q9H7T5, Q9NR17, Q9NUN2, Q9NZ79 A4D0S1, C9JZI4
UniProt Related Accession:Q9NP80
Molecular Weight:77,031 Da
NCBI Full Name:Calcium-independent phospholipase A2-gamma
NCBI Synonym Full Names:patatin like phospholipase domain containing 8
NCBI Official Symbol:PNPLA8  
NCBI Official Synonym Symbols:MMLA; IPLA2G; IPLA2-2; iPLA2gamma; PNPLA-gamma  
NCBI Protein Information:calcium-independent phospholipase A2-gamma
UniProt Protein Name:Calcium-independent phospholipase A2-gamma
UniProt Synonym Protein Names:Intracellular membrane-associated calcium-independent phospholipase A2 gamma; iPLA2-gamma; PNPLA-gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-2
Protein Family:Calcium-independent phospholipase
UniProt Gene Name:PNPLA8  
UniProt Entry Name:PLPL8_HUMAN
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