The PNPLA8 Polyclonal Antibody (PACO00978) is a valuable tool for researchers studying PNPLA8, a protein involved in lipid metabolism and energy homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding to PNPLA8, this antibody enables accurate detection and analysis of the protein in various cell types, making it an ideal choice for studies in metabolism, obesity, and related fields.PNPLA8, also known as adiponutrin, plays a crucial role in lipid droplet metabolism and triglyceride turnover in cells.
Dysregulation of PNPLA8 has been linked to metabolic disorders such as obesity, fatty liver disease, and insulin resistance. Research on PNPLA8 is therefore important for understanding the mechanisms underlying these conditions and developing targeted therapeutics.Overall, the PNPLA8 Polyclonal Antibody offers researchers a reliable tool for investigating the role of PNPLA8 in lipid metabolism and related metabolic disorders, ultimately contributing to advancements in the field of metabolic research.
Antibody Name:
PNPLA8 Antibody
Antibody SKU:
PACO00978
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human iPLA2gamma.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
PNPLA8: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; EC 3.1.1.5; Phospholipase; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 7q31Cellular Component: endoplasmic reticulum membrane; intracellular; membrane; peroxisomal membrane; peroxisomeMolecular Function: calcium-independent phospholipase A2 activity; phospholipase A2 activityBiological Process: arachidonic acid metabolic process; arachidonic acid secretion; cell death; fatty acid metabolic process; linoleic acid metabolic process; phosphatidylethanolamine catabolic process; prostaglandin biosynthetic processDisease: Mitochondrial Myopathy With Lactic Acidosis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]
