PNPLA6 Antibody (PACO22471)
- SKU:
- PACO22471
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PNPLA6 Antibody (PACO22471)
The PNPLA6 Antibody (PAC022471) is a valuable tool for researchers studying the PNPLA6 protein, which is involved in lipid metabolism and neurological disorders. This polyclonal antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to PNPLA6, the antibody allows for detection and analysis of the protein in various cell types, making it ideal for investigations in neuroscience and lipid biology.PNPLA6, also known as neuropathy target esterase (NTE), plays a crucial role in lipid droplet metabolism and phospholipid biosynthesis in the brain.
Mutations in the PNPLA6 gene have been linked to neurological conditions such as Boucher-Neuhauser syndrome and spastic paraplegia. Understanding the function of PNPLA6 is essential for unraveling the mechanisms underlying these diseases and developing potential therapeutic interventions. Overall, the PNPLA6 Antibody (PAC022471) is a reliable tool for researchers interested in studying PNPLA6 and its role in lipid metabolism and neurological disorders. Its specificity and versatility make it a valuable asset in advancing our understanding of these complex biological processes.
| Antibody Name: | PNPLA6 Antibody (PACO22471) |
| Antibody SKU: | PACO22471 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human PNPLA6. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO205 cells, using PNPLA6 antibody. |
| Background: | Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. |
| Synonyms: | Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6; |
| UniProt Protein Function: | NTE: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Defects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39); also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles. Belongs to the NTE family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Hydrolase; EC 3.1.1.5 Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane Molecular Function:lysophospholipase activity Biological Process: developmental process; glycerophospholipid catabolic process Disease: Boucher-neuhauser Syndrome; Laurence-moon Syndrome; Oliver-mcfarlane Syndrome; Spastic Paraplegia 39, Autosomal Recessive |
| NCBI Summary: | This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q8IY17 |
| NCBI GenInfo Identifier: | 150403921 |
| NCBI Gene ID: | 10908 |
| NCBI Accession: | Q8IY17.2 |
| UniProt Secondary Accession: | Q8IY17,O60859, Q86W58, Q9UG58, A6NGQ0, B4DFB9, B7Z7T2 F5H5K9, J3KQS3, |
| UniProt Related Accession: | Q8IY17 |
| Molecular Weight: | 143,351 Da |
| NCBI Full Name: | Neuropathy target esterase |
| NCBI Synonym Full Names: | patatin like phospholipase domain containing 6 |
| NCBI Official Symbol: | PNPLA6Â Â |
| NCBI Official Synonym Symbols: | NTE; sws; BNHS; LNMS; OMCS; SPG39; NTEMND; iPLA2delta  |
| NCBI Protein Information: | neuropathy target esterase |
| UniProt Protein Name: | Neuropathy target esterase |
| UniProt Synonym Protein Names: | Patatin-like phospholipase domain-containing protein 6 |
| Protein Family: | Neuropathy target esterase |
| UniProt Gene Name: | PNPLA6Â Â |
| UniProt Entry Name: | PLPL6_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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