The PNPLA3 Polyclonal Antibody (CAB6694) is a valuable research tool for studying the PNPLA3 protein, a key player in lipid metabolism and liver function. This antibody, derived from rabbit serum, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PNPLA3 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an essential tool for studies in metabolic disorders and liver diseases.PNPLA3, also known as adiponutrin, is a lipase enzyme that plays a critical role in lipid droplet metabolism, triglyceride storage, and energy homeostasis. Mutations in the PNPLA3 gene have been associated with liver conditions such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), making it a promising target for therapeutic interventions.
Understanding the function and regulation of PNPLA3 is essential for developing treatments for these prevalent liver disorders.In summary, the PNPLA3 Polyclonal Antibody is a reliable tool for researchers interested in investigating the role of PNPLA3 in lipid metabolism, liver diseases, and metabolic disorders. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of the molecular mechanisms underlying these diseases and identifying potential therapeutic targets.
Product Name:
PNPLA3 Rabbit Polyclonal Antibody
SKU:
CAB6694
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 377-481 of human PNPLA3 (NP_079501.2).
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
Purification Method:
Affinity purification
Gene ID:
80339
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PNPLA3 Rabbit pAb (CAB6694) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
