The PNN Polyclonal Antibody (CAB16954) is a valuable tool for researchers studying PNN, a protein involved in synaptic plasticity and neuronal development. This rabbit-derived antibody is highly specific to human samples and has been validated for use in applications such as Western blotting. By targeting the PNN protein, this antibody allows for detection and analysis in various cell types, making it ideal for studies in neuroscience and neurology.PNN, or perineuronal nets, are specialized extracellular matrix structures found around certain neurons in the brain. They play a crucial role in regulating synaptic plasticity, neuronal excitability, and neuroprotection.
Understanding the function of PNN is important for unraveling the mechanisms underlying brain development, learning, and memory formation. Additionally, abnormalities in PNN have been linked to neurodevelopmental disorders and neurodegenerative diseases, making it a promising target for therapeutic interventions.The PNN Polyclonal Antibody (CAB16954) offers researchers a reliable tool for investigating the role of PNN in various physiological and pathological conditions, paving the way for new insights into brain function and potential therapeutic strategies.
Product Name:
PNN Rabbit Polyclonal Antibody
SKU:
CAB16954
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNN (NP_002678.2).
Enables RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Predicted to act upstream of or within cell-cell adhesion. Located in nuclear speck. Part of catalytic step 2 spliceosome. Colocalizes with exon-exon junction complex.
Purification Method:
Affinity purification
Gene ID:
5411
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PNN Rabbit pAb (CAB16954) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 120s.
