The PNN Polyclonal Antibody (CAB16955) is a specialized research tool designed for studying PNN, a protein involved in regulating neuronal plasticity and synaptic function. This antibody, produced in rabbits, is highly specific for detecting PNN in human samples and is validated for use in immunofluorescence and immunohistochemistry applications. By binding to the PNN protein, this antibody enables researchers to visualize and analyze PNN expression in various tissues and cell types, making it a valuable tool for studies in neuroscience and brain research.PNN, also known as perineuronal nets, play a crucial role in stabilizing synapses and modulating neural circuit function in the brain.
Abnormalities in PNN expression have been linked to various neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease. By studying the function of PNN using this antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment. Understanding the role of PNN in neuronal plasticity and synaptic function is essential for advancing our knowledge of brain development and function.
Product Name:
PNN Rabbit Polyclonal Antibody
SKU:
CAB16955
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNN (NP_002678.2).
Enables RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Predicted to act upstream of or within cell-cell adhesion. Located in nuclear speck. Part of catalytic step 2 spliceosome. Colocalizes with exon-exon junction complex.
Purification Method:
Affinity purification
Gene ID:
5411
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PNN Rabbit pAb (CAB16955) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
