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PNMT Monoclonal Antibody [PAT1C11] (CPAB0113)

SKU:
CPAB0113
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT1C11
Applications:
WB
ELISA
$179

Description

system_update_alt Datasheet

PNMT Monoclonal Antibody [PAT1C11] (CPAB0113)

The PNMT Polyclonal Antibody (CPAB0113) is a valuable tool for researchers studying the enzyme PNMT, which is involved in the biosynthesis of the neurotransmitter norepinephrine. This antibody, raised in rabbits, is highly specific for human PNMT and has been validated for use in various applications, including Western blotting.PNMT, or Phenylethanolamine N-methyltransferase, is an important enzyme in the regulation of norepinephrine levels, which play a key role in the sympathetic nervous system. Dysregulation of PNMT has been implicated in various diseases, including hypertension and heart failure, making it a promising target for therapeutic interventions.

With its high reactivity and specificity for human PNMT, the CPAB0113 antibody is an essential tool for researchers investigating the role of PNMT in health and disease. Its use in Western blot applications allows for the detection and analysis of PNMT protein levels in various cell types, facilitating studies in neuroscience, cardiology, and endocrinology.

Product Name:PNMT Antibody
Product Sku:CPAB0113
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PNMT, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ADK amino acids 1-282 purified from Ecoli.
Clone:PAT1C11.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:PNMT antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:PNMT is an enzyme located in the adrenal medulla and it catalyzes the final step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). PNMT has beta-carboline 2N-methyltransferase activity. PNMT takes part in regulating epinephrine production. Glucocorticoid receptors form multimers of PNMT independent of the DNA binding domain. PNMT expression is regulated late in mouse gestation by AP2-alpha and glucocorticoids.
Synonyms:PENT, PNMTase, Noradrenaline-N-methyltransferase, Phenylethanolamine N-methyltransferase, PNMT, MGC34570.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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