The PNKP Monoclonal Antibody is a valuable tool for researchers studying PNKP, a crucial enzyme involved in DNA repair and cellular responses to DNA damage. This antibody, produced using advanced monoclonal technology, exhibits high specificity and sensitivity towards PNKP in various experimental settings, including immunofluorescence and immunoprecipitation.PNKP plays a vital role in maintaining genomic stability by repairing DNA strand breaks and promoting cell survival under genotoxic stress. Dysregulation of PNKP has been linked to various genetic disorders and cancers, highlighting its importance in maintaining cellular integrity. By targeting PNKP using this monoclonal antibody, researchers can gain valuable insights into the mechanisms underlying DNA repair processes and potential therapeutic strategies for cancer treatment.
Overall, the PNKP Monoclonal Antibody is a reliable tool for investigating the functions of PNKP in DNA repair pathways, making it an essential addition to any research study focusing on genomics, cancer biology, or molecular genetics. Its high specificity and versatility make it a valuable asset for unraveling the complexities of DNA damage response mechanisms and developing targeted therapies for diseases associated with genomic instability.
Product Name:
PNKP Monoclonal Antibody
SKU:
CAB21145
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of Human PNKP (NP_009185.2).
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
Purification Method:
Affinity purification
Gene ID:
11284
Clone Number:
ARC2974
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PNKP Rabbit mAb (CAB21145) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
