The PNCK Polyclonal Antibody (PAC023355) is a valuable tool for researchers studying PNCK, a protein kinase enzyme involved in various cellular processes. This antibody is raised in rabbits and is highly specific to human samples, allowing for reliable results in Western blot applications. By binding to PNCK, this antibody enables researchers to detect and analyze the protein in different cell types, making it ideal for studies in cell signaling, cancer biology, and neurobiology.PNCK is known for its role in regulating cell growth, proliferation, and differentiation, making it a potential target for therapeutic interventions in cancer and other diseases.
Understanding the function of PNCK is crucial for developing targeted therapies that can selectively inhibit or activate its activity, providing new avenues for treatment options in various disease settings.Overall, the PNCK Polyclonal Antibody is a valuable tool for researchers looking to delve into the complex mechanisms of PNCK and its implications in cellular physiology and disease progression. Its high specificity and sensitivity make it a reliable choice for studying PNCK biology in a wide range of research applications.
Synthesized peptide derived from internal of human CaMK1- beta .
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from LOVO cells, treated with H2O2 (100uM, 30mins), using CaMK1- beta antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using CaMK1- beta antibody.
Background:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 By similarity.
Synonyms:
Calcium/calmodulin-dependent protein kinase type 1B; EC 2.7.11.17; CaM kinase IB; CaM kinase I beta; CaMKI-beta
UniProt Protein Function:
CAMK1B: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; CAMK group; CAMK1 family
Chromosomal Location of Human Ortholog: Xq28
NCBI Summary:
PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]
