The PMVK Polyclonal Antibody (CAB13865) is a valuable tool for researchers studying the PMVK protein, which plays a crucial role in the mevalonate pathway. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the PMVK protein, this antibody allows for the detection and analysis of PMVK in various cell types, making it an ideal choice for research in biochemistry and molecular biology.
The mevalonate pathway is essential for the biosynthesis of important molecules such as cholesterol, steroid hormones, and isoprenoids. Disruptions in this pathway can lead to various diseases, making PMVK a potential therapeutic target for conditions like hypercholesterolemia and cancer. By studying the activity of the PMVK protein, researchers can gain valuable insights into the regulation of this pathway and potentially develop new treatments for related disorders.
Product Name:
PMVK Rabbit Polyclonal Antibody
SKU:
CAB13865
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human PMVK (NP_006547.1).
This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10654
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PMVK Rabbit pAb (CAB13865) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
